📚 Reference: NMDA Receptors High-Yield
- EPSP Mechanism Glutamate binds NMDA receptor → Influx of Calcium (Ca²⁺) and Sodium (Na⁺) > Efflux of Potassium (K⁺) → Net Depolarization.
- Synaptic Plasticity (LTP) Increased Ca²⁺ entry initiates second-messenger signaling (e.g., Protein Kinase C) → Strengthens synaptic connections (basis of memory).
- Acute Blockade (Amnesia) Drugs like Ketamine and PCP acutely block NMDA receptors, disrupting LTP and causing amnesia.
- Chronic Blockade (Neuroprotection) Drugs like Memantine (for Alzheimer's) dampen glutamate-induced excitotoxicity (neuron death due to Ca²⁺ overload).