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MEN Syndromes Reference
MEN 1 (Wermer Syndrome)
Mnemonic: The 3 P's
1. Pituitary Adenomas
2. Parathyroid Hyperplasia
3. Pancreatic Tumors
- Gene: MEN1 (Tumor Suppressor) on Chromosome 11.
- Presentation: Kidney stones (hypercalcemia), ulcers (gastrinoma), visual field defects (pituitary).
- Tumor Types: Gastrinoma (Zollinger-Ellison), Insulinoma, VIPoma, Prolactinoma.
MEN 2A (Sipple Syndrome)
Mnemonic: 2 P's and 1 M
1. Parathyroid Hyperplasia
2. Pheochromocytoma
3. Medullary Thyroid Carcinoma
- Gene: RET (Proto-oncogene) on Chromosome 10.
- Key Feature: Medullary Thyroid Carcinoma (MTC) secretes Calcitonin.
- Associations: Cutaneous Lichen Amyloidosis.
MEN 2B
Mnemonic: 1 P and 2 M's
1. Pheochromocytoma
2. Medullary Thyroid Carcinoma
3. Mucosal Neuromas
- Gene: RET (Proto-oncogene).
- Physical Exam: Marfanoid habitus (tall/lanky), fleshy bumps on lips/tongue (neuromas).
- Difference: NO Parathyroid involvement. MTC is more aggressive.