Cholinergic Agonists

Drug	Mechanism	Clinical Uses	Notes / Mnemonics
Bethanechol	Agonist at M3	Urinary retention, ileus	"Bethany, call me"
Carbachol	Agonist at M1-M3, Nicotinic	Glaucoma	"Carbon copy"
Methacholine	Agonist at M3 (Airway)	Asthma challenge
Pilocarpine	Agonist at M3	Glaucoma, Sjogren's	"Cry, drool, sweat"
Donepezil, Rivastigmine, Galantamine	Anti-AChE (Central)	Alzheimer's	Crosses BBB
Edrophonium	Anti-AChE (NMJ)	MG Diagnosis	Short acting
Neostigmine	Anti-AChE (NMJ)	MG, Ileus, Reversal	No CNS entry
Physostigmine	Anti-AChE (CNS/PNS)	Atropine overdose	Crosses BBB
Pyridostigmine	Anti-AChE (NMJ)	MG Maintenance	Long acting

Anticholinergics

Drug	Mechanism	Clinical Uses	Notes / Mnemonics
Atropine, Homatropine, Tropicamide	Antagonist at M1-M3	Mydriasis, Bradycardia	"Hot as a hare"
Benztropine, Trihexyphenidyl	Antagonist at M1 (CNS)	Parkinson's	"Park my Benz"
Glycopyrrolate	Antagonist at M3 (Glands)	Drooling, Secretions	No CNS entry
Hyoscyamine, Dicyclomine	Antagonist at M3 (GI)	IBS	Antispasmodic
Ipratropium, Tiotropium	Antagonist at M3 (Airway)	COPD, Asthma	"I pray I can breathe"
Oxybutynin, Solifenacin, Tolterodine	Antagonist at M3 (Bladder)	Overactive Bladder
Scopolamine	Antagonist at M1 (Vestibular)	Motion Sickness	Patch

Sympathomimetics

Drug	Mechanism	Clinical Uses	Notes / Mnemonics
Albuterol, Salmeterol	Agonist at Beta-2	Asthma, COPD	Salmeterol = Long acting
Dobutamine	Agonist at Beta-1 > Beta-2	Heart Failure	Inotropic
Dopamine	D1 (low), B1 (med), A1 (high)	Shock, HF	Dose dependent
Epinephrine	Agonist at Beta > Alpha	Anaphylaxis
Fenoldopam	Agonist at D1	HTN Emergency	Renal vasodilation
Isoproterenol	Agonist at Beta-1 = Beta-2	Arrhythmia eval	Drops DBP
Midodrine	Agonist at Alpha-1	Postural Hypotension	Oral active
Mirabegron	Agonist at Beta-3	Overactive Bladder
Norepinephrine	Agonist at Alpha-1 > Beta-1	Septic Shock	Reflex bradycardia
Phenylephrine	Agonist at Alpha-1	Decongestant, Mydriatic	Pure pressor
Amphetamine	Displaces NE/DA	ADHD	Indirect
Cocaine	Inhibits NET/DAT	Anesthesia	Indirect
Ephedrine	Releases NE	Decongestant	Mixed

Sympatholytics

Drug	Mechanism	Clinical Uses	Notes / Mnemonics
Prazosin, Terazosin, Doxazosin	Antagonist at Alpha-1	BPH, HTN, PTSD	1st dose hypotension
Tamsulosin	Antagonist at Alpha-1A	BPH (Uroselective)
Phenoxybenzamine	Irreversible Alpha block	Pheochromocytoma	Covalent bond
Phentolamine	Reversible Alpha block	Tyramine crisis	Competitive
Clonidine, Guanfacine	Agonist at Alpha-2 (Central)	HTN, ADHD	Rebound HTN
Alpha-Methyldopa	Agonist at Alpha-2 (Central)	HTN in pregnancy	Coombs +
Propranolol, Nadolol, Timolol	Antagonist at Beta-1, Beta-2	HTN, Glaucoma (Timolol)	Non-selective
Atenolol, Metoprolol, Esmolol, Bisoprolol	Antagonist at Beta-1	HTN, HF, CAD	Cardioselective
Carvedilol, Labetalol	Antagonist at B1, B2, A1	HF, HTN Pregnancy	Vasodilating
Acebutolol, Pindolol	Partial Agonist (ISA)	HTN	Avoid in Angina