Diagnosis
| Pathology | Target | Marker |
|---|---|---|
| Carcinomas | Epithelial | Cytokeratin |
| Sarcomas | Mesenchymal | Vimentin |
| Rhabdomyosarcoma | Muscle | Desmin / Myogenin |
| Glioblastoma | Neuroglia | GFAP |
| Neuroblastoma | Neurons | Neurofilament |
| Pathology | Target | Marker |
|---|---|---|
| Lymphoma Screen | Leukocytes | CD45 (LCA) |
| Hodgkin Lymphoma | Reed-Sternberg | CD15 / CD30 |
| B-Cell Lymphoma | B-cells | CD20 |
| T-Cell Lymphoma | T-cells | CD3 |
| Angiosarcoma | Endothelium | CD34 / CD31 |
| ALL (Acute Lymphoblastic) | Lymphoblasts | TdT |
| AML (Acute Myeloid) | Myeloid | MPO |
| Hairy Cell Leukemia | Hairy Cells | CD11c / TRAP |
| CLL / Mantle Cell | CD5+ B-cells | CD5 |
| PNH | RBCs | Absence of CD55/59 |
| Pathology | Marker/Stain |
|---|---|
| Melanoma | S-100 / HMB-45 / BRAF V600E |
| Neuroendocrine | Chromogranin / Synaptophysin |
| Lung Adenocarcinoma | TTF-1 |
| Prostate Cancer | PSA |
| Liver (HCC) | HepPar-1 |
| Ovarian Cancer | CA-125 |
| Colorectal Cancer | CEA |
| Burkitt Lymphoma | t(8;14) c-myc |
| Follicular Lymphoma | t(14;18) Bcl-2 |
| Mantle Cell | t(11;14) Cyclin D1 |
| Ewing Sarcoma | t(11;22) EWS-FLI1 |