Question
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Thyroid Pathology
Visual Diagnostics
Accuracy
100%
Reference
⚠️ Image file not found.
Ensure files are named:
atrophy.png, graves.png, medullary.png,
dequervain.png, hashimoto.png
Clinical Scenario
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Which condition is consistent with these findings?
Explanation
Next Case ➡
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Thyroid Pathology Reference
Condition
Pathogenesis
Histology / Key Features
Tg & RAIU
Hashimoto Thyroiditis
Autoimmune (Anti-TPO, Anti-Tg). T-cell destruction.
Lymphocytic infiltrate, Germinal centers, Hurthle cells.
High Tg. Variable RAIU (usually low if hypothyroid).
De Quervain (Subacute)
Post-viral inflammatory response.
Granulomatous inflammation, Multinucleated Giant Cells.
PAINFUL
.
High Tg (leakage).
Very Low RAIU
.
Graves Disease
Autoimmune (TSI activates TSH-R).
Tall crowded epithelium, Scalloping of colloid. Exophthalmos.
High Tg (synthesis).
High RAIU
(diffuse).
Exogenous Thyrotoxicosis
Factitious ingestion of T4/T3.
Follicular Atrophy
(Small follicles due to TSH suppression).
LOW Tg
.
Low RAIU
.
Medullary Carcinoma
Parafollicular C-cell tumor (MEN 2A/2B).
Amyloid deposits (Calcitonin), Nests of polygonal cells.
Normal Tg.
Calcitonin
is the marker.
💡 Quick Tips & Mnemonics
Hashimoto
has
H
urthle cells and
H
eaps of lymphocytes (Germinal centers).
De Quervain
=
Pain
(Rhymes). Post-viral granulomas.
Graves
=
Waves
(Scalloped colloid looks like waves).
Exogenous
intake puts the thyroid to sleep (
Atrophy
) and stops factory production (
Low Thyroglobulin
).
Medullary
=
MEN
syndromes. Amyloid from Calcitonin.
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