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USMLE Step 1: Uterine Pharmacology
| Drug | Effect | Mechanism | Clinical Use |
|---|
Mnemonics & Tips
Tocolytics ("It's Not My Time"): Indomethacin, Nifedipine, Magnesium Sulfate, Terbutaline.
Mechanism Tip: Relaxation (Tocolysis) requires $\downarrow$ intracellular $Ca^{2+}$ or inhibition of **MLCK**. Terbutaline acts via $G_s$, Oxytocin via $G_q$.
Side Effect Pearl: Terbutaline $\rightarrow$ pulmonary edema. Nifedipine $\rightarrow$ flushing/hypotension. Indomethacin $\rightarrow$ premature closure of ductus arteriosus.